快盈:科研(yan)成果
快盈:中农颖(ying)泰，让(rang)抗菌(jun)肽造福(fu)全人类!
抗(kang)(kang)(kang)菌(jun)(jun)(jun)肽(tai)(tai)又称抗(kang)(kang)(kang)微(wei)(wei)生(sheng)(sheng)(sheng)(sheng)物(wu)(wu)(wu)肽(tai)(tai)或宿主防(fang)御(yu)肽(tai)(tai)，是(shi)生(sheng)(sheng)(sheng)(sheng)物(wu)(wu)(wu)体(ti)经(jing)诱(you)导(dao)产(chan)(chan)(chan)(chan)(chan)(chan)生(sheng)(sheng)(sheng)(sheng)的(de)(de)具(ju)有(you)广(guang)谱抗(kang)(kang)(kang)菌(jun)(jun)(jun)活性(xing)和免(mian)(mian)(mian)疫调节活性(xing)的(de)(de)一(yi)类小分(fen)(fen)子多(duo)肽(tai)(tai)，属于(yu)机(ji)体(ti)非(fei)特异性(xing)防(fang)御(yu)系统(tong)的(de)(de)固有(you)组(zu)成(cheng)(cheng)(cheng)(cheng)部(bu)分(fen)(fen)，几乎存在于(yu)所(suo)有(you)生(sheng)(sheng)(sheng)(sheng)命形式中(zhong)。抗(kang)(kang)(kang)菌(jun)(jun)(jun)肽(tai)(tai)通常由12-50个(ge)氨(an)基酸组(zu)成(cheng)(cheng)(cheng)(cheng)，相对(dui)分(fen)(fen)子质量(liang)一(yi)般(ban)在4kDa左右。研(yan)究发(fa)现，抗(kang)(kang)(kang)菌(jun)(jun)(jun)肽(tai)(tai)具(ju)有(you)快速杀菌(jun)(jun)(jun)和广(guang)谱抗(kang)(kang)(kang)菌(jun)(jun)(jun)活性(xing)，包(bao)括抗(kang)(kang)(kang)革(ge)兰氏(shi)阳(yang)性(xing)菌(jun)(jun)(jun)、革(ge)兰氏(shi)阴性(xing)菌(jun)(jun)(jun)、多(duo)重耐药(yao)细(xi)菌(jun)(jun)(jun)、真(zhen)菌(jun)(jun)(jun)、寄(ji)生(sheng)(sheng)(sheng)(sheng)虫(chong)、包(bao)膜病(bing)毒和肿(zhong)瘤细(xi)胞(bao)(bao)，并(bing)能在先天(tian)性(xing)免(mian)(mian)(mian)疫和获得(de)性(xing)免(mian)(mian)(mian)疫反(fan)应之间(jian)起(qi)到桥梁作(zuo)用，通过(guo)(guo)启动(dong)(dong)获得(de)性(xing)免(mian)(mian)(mian)疫系统(tong)提(ti)(ti)(ti)高(gao)(gao)机(ji)体(ti)抵(di)抗(kang)(kang)(kang)微(wei)(wei)生(sheng)(sheng)(sheng)(sheng)物(wu)(wu)(wu)感染的(de)(de)能力。迄今(jin)为(wei)(wei)止，已发(fa)现超(chao)过(guo)(guo)4000种抗(kang)(kang)(kang)菌(jun)(jun)(jun)肽(tai)(tai)。天(tian)蚕(can)(can)素(su)是(shi)世界(jie)上(shang)第一(yi)个(ge)被发(fa)现的(de)(de)抗(kang)(kang)(kang)菌(jun)(jun)(jun)肽(tai)(tai)，1980年(nian)由瑞典科学(xue)家 Boman 等(deng)(deng)人(ren)从惜(xi)古(gu)比天(tian)蚕(can)(can)蛹中(zhong)诱(you)导(dao)分(fen)(fen)离得(de)到，其由37个(ge)氨(an)基酸组(zu)成(cheng)(cheng)(cheng)(cheng)，分(fen)(fen)子量(liang)为(wei)(wei)3800Da。天(tian)蚕(can)(can)素(su)的(de)(de)杀菌(jun)(jun)(jun)机(ji)理(li)独特，不(bu)产(chan)(chan)(chan)(chan)(chan)(chan)生(sheng)(sheng)(sheng)(sheng)耐药(yao)性(xing)，绿色(se)安(an)全无药(yao)残，对(dui)常见病(bing)原微(wei)(wei)生(sheng)(sheng)(sheng)(sheng)物(wu)(wu)(wu)作(zuo)用效果均显(xian)著(zhu)，并(bing)能通过(guo)(guo)趋化(hua)(hua)(hua)树突(tu)状细(xi)胞(bao)(bao)、单核细(xi)胞(bao)(bao)和记忆(yi)T细(xi)胞(bao)(bao)，显(xian)著(zhu)提(ti)(ti)(ti)高(gao)(gao)机(ji)体(ti)免(mian)(mian)(mian)疫力，是(shi)世界(jie)上(shang)公认的(de)(de)抗(kang)(kang)(kang)生(sheng)(sheng)(sheng)(sheng)素(su)替代品。目前抗(kang)(kang)(kang)菌(jun)(jun)(jun)肽(tai)(tai)的(de)(de)生(sheng)(sheng)(sheng)(sheng)产(chan)(chan)(chan)(chan)(chan)(chan)方法主要(yao)有(you)三(san)种：天(tian)然提(ti)(ti)(ti)取、化(hua)(hua)(hua)学(xue)合(he)(he)成(cheng)(cheng)(cheng)(cheng)和生(sheng)(sheng)(sheng)(sheng)物(wu)(wu)(wu)工程(cheng)合(he)(he)成(cheng)(cheng)(cheng)(cheng)。天(tian)然抗(kang)(kang)(kang)菌(jun)(jun)(jun)肽(tai)(tai)主要(yao)来自(zi)昆虫(chong)，但其提(ti)(ti)(ti)取过(guo)(guo)程(cheng)甚为(wei)(wei)复杂；化(hua)(hua)(hua)学(xue)合(he)(he)成(cheng)(cheng)(cheng)(cheng)方法成(cheng)(cheng)(cheng)(cheng)本高(gao)(gao)昂，不(bu)适(shi)于(yu)产(chan)(chan)(chan)(chan)(chan)(chan)业(ye)化(hua)(hua)(hua)；生(sheng)(sheng)(sheng)(sheng)物(wu)(wu)(wu)工程(cheng)合(he)(he)成(cheng)(cheng)(cheng)(cheng)方法是(shi)通过(guo)(guo)对(dui)现有(you)抗(kang)(kang)(kang)菌(jun)(jun)(jun)肽(tai)(tai)进(jin)行改良(liang)，利用微(wei)(wei)生(sheng)(sheng)(sheng)(sheng)物(wu)(wu)(wu)进(jin)行表(biao)达，提(ti)(ti)(ti)高(gao)(gao)其表(biao)达量(liang)，利用发(fa)酵技术实现产(chan)(chan)(chan)(chan)(chan)(chan)业(ye)化(hua)(hua)(hua)，具(ju)备质量(liang)稳定、成(cheng)(cheng)(cheng)(cheng)本低等(deng)(deng)优势，是(shi)业(ye)界(jie)公认的(de)(de)规模(mo)化(hua)(hua)(hua)生(sheng)(sheng)(sheng)(sheng)产(chan)(chan)(chan)(chan)(chan)(chan)的(de)(de)更佳途径。在林州红旗渠经(jing)济技术开发(fa)区拥(yong)有(you)1037亩(mu)的(de)(de)生(sheng)(sheng)(sheng)(sheng)物(wu)(wu)(wu)产(chan)(chan)(chan)(chan)(chan)(chan)业(ye)区，建(jian)(jian)成(cheng)(cheng)(cheng)(cheng)国际的(de)(de)抗(kang)(kang)(kang)菌(jun)(jun)(jun)肽(tai)(tai)、益(yi)生(sheng)(sheng)(sheng)(sheng)菌(jun)(jun)(jun)、生(sheng)(sheng)(sheng)(sheng)物(wu)(wu)(wu)饲料(liao)(liao)和蛋白原料(liao)(liao)生(sheng)(sheng)(sheng)(sheng)产(chan)(chan)(chan)(chan)(chan)(chan)线。拥(yong)有(you)国内外的(de)(de)抗(kang)(kang)(kang)菌(jun)(jun)(jun)肽(tai)(tai)生(sheng)(sheng)(sheng)(sheng)物(wu)(wu)(wu)发(fa)酵、纯(chun)化(hua)(hua)(hua)、干燥和检测设备，建(jian)(jian)立了集(ji)食品添加(jia)剂(ji)、生(sheng)(sheng)(sheng)(sheng)物(wu)(wu)(wu)医(yi)药(yao)、科技大厦、动(dong)(dong)物(wu)(wu)(wu)实验(yan)中(zhong)心、活动(dong)(dong)中(zhong)心、商学(xue)院等(deng)(deng)于(yu)一(yi)体(ti)的(de)(de)抗(kang)(kang)(kang)菌(jun)(jun)(jun)肽(tai)(tai)生(sheng)(sheng)(sheng)(sheng)物(wu)(wu)(wu)产(chan)(chan)(chan)(chan)(chan)(chan)业(ye)园区。
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